QLD
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Research Group : Main Protease
Interest
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Abbenante
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UQ
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New approaches to
inhibitors of aspartic/serine/cysteine/metallo proteases
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Alewood
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UQ
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Chemical
synthesis & engineering of proteases, active site mechanisms
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Blanchard
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GU
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Calpains and
caspases; protein crystal structure structures
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Bottle
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QUT
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Antioxidants to
retard free radical oxidation of proteins and activation of
proteases
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Brinkworth
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UQ
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Homology
modelling , enzymology, aspartic/serine/cysteine/metallo proteases
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Clements
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QUT
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Genetics,
structure and functions of kallikreins, hormone regulation,
cancers
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Craik
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UQ
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NMR-derived
structures of plant proteases & proteinaceous inhibitors,
cyclotides
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Deeth
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UQ
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Proteases in milk : plasmin and cathepsins,
extracellular bacterial proteases
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Dong
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QUT
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Kallikreins in
ovarian cancer, breast cancer and endometrial carcinomas
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Fairlie
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UQ
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Inhibitors of
aspartic/serine/metallo/cysteine/threonine proteases, PAR ligands
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Fischer
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QIMR
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Serine proteases
and homologues from scabies parasites
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Gorman
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UQ
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Proteomics,
host/viral proteases and viral infection; proteolysis analysis
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Harris
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QUT
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Molecular
modelling and expression of kallikreins, phage displays for
inhibition
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Herrington
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QUT
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Roles and
regulation of ADAMs and involvement in prostate cancer
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Hooper
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QUT
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Molecular/cell
biology and enzymology of TTSRs and kallikreins in cancer
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Kemp
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QIMR
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Serine proteases
and homologues from scabies parasites
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Kobe
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UQ
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Protease
structure/function/genomics; Schisto cathepsin D, latexin,
autoregulation
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Lavin
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QIMR
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developmental
genetics, novel proteases and inhibitors from snake venoms
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Lewis
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UQ
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Proteases related
to generation of toxins (e.g. conotoxins and venom proteases)
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Loughlin
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GU
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Synthesis of
beta-strand mimicking molecules as protease inhibitors
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Loukas
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QIMR
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Intestinal
hookworm proteases as vaccines and targets for drugs
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Martin
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UQ
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Crystal
structures viral proteases, protease-ligand complexes, protein
inhibitors
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Masci
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PAH
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Proteases and
inhibitors from snake venoms and hemostasis
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Odorico
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QUT
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Regulation of
ADAMs and kallikreins in cancer, prostate cancer
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Reid
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UQ
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Protease
inhibitors, drug design and synthesis, beta strand mimetics
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Stoermer
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UQ
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Protease
inhibitors, drug design and synthesis, viral proteases
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Tyndall
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UQ
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Modelling/structural
studies of protease-ligand recognition, inhibitor design
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Walsh
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QUT
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Proteases in biological activation/regulation,
prokallikreins, insect proteases
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Watters
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GU
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Caspases and
inhibitors associated with tumour resistance to apoptosis
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Whiteside
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QUT
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Metalloproteases
and TIMPs in osseointegration and bone
remodelling
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Young
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UQ
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Serine proteases
as antiviral targets and vaccines; flaviviruses.
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WA
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Bhoola
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UWA
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Kallikrein-kinin
system in immune cells, inflammation, asthma, COPD
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Henry
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UWA
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PARs in the
airways and lung function; epithelial proteases; allergens, asthma
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Lan
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UWA
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PARs in the
airways
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Misso
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UWA
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Plasma/tissue
kallikreins in asthma, chronic obstructive pulmonary disease.
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Mitchell
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UWA
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PARs, proteases,
PGE2; physiology of the airway, development of airway
cells
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Smith
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UWA
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Proteases as
allergens from dust mites, allergy and asthma
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Stacey
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UWA
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PARs and wound
healing
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Stewart
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UWA
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Serine and
cysteine proteases as allergens and PARs
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Thomas
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UWA
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Protease
allergens from dust mites
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Thompson
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UWA
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Kallikrein-kinin
system in immune cells, inflammation, asthma, COPD
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NSW
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Curmi
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SYD
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NMR-derived
structure determination and PAI-II
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Dalton
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UTS
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Protease in
parasitology (malaria, schistosomiasis, liver flukes)
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Di Girolamo
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NSW
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UVB-induction of
MMPs and pro-inflammatory cytokines in ocular epithelial cells
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Gorrell
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SYD
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Dipeptidyl
peptidase IV genes in diabetes, apoptosis, cancer, fibrosis
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Guss
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SYD
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Protein
crystallography and Amino peptidases
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Hogg
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NSW
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Fibrinolysis,
plasmin/tissuefactor serine proteases, reversible disulfides
switches
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Hunt
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NSW
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Mast cell
proteases, asthma
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Jackson
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SYD
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Metalloproteases
and protein C, wound healing, arthritis, diabetes and pregnancy
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Little
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SYD
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Aggrecan
proteolysis; cartilage, disc, tendon degradation;
MMPs, ADAMTS
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Rodgers
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HRI
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Proteasomes and
lysosomes in proteolysis of oxidised proteins
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Russell
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NSW
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proteases in the
invasion and metastases of (particularly bladder, prostate) cancer
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Wang
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NSW
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Urokinase/UPA
receptor, serine proteases, cell migration, angiogenesis,
metastisis
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Wouters
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NSW
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Bioinformatics
and evolution of proteases, design of serine proteases
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VIC
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Aguilar
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MON
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Cardiovascular
metalloproteases, beta amino acids in inhibitors, neuropeptides
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Anderson
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LaTr
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Insect/plant
proteases/inhibitors, mutated chymotrypsins, crop protection
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Bird
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MON
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Molecular/cell
biology of serpins, folding, granzyme B, cathepsin G
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Bottomley
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MON
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Serpins and
serine proteases, biophysics, kinetics, folding, enzymology
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Chai
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MEL
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Brain ACE, IRAP,
Parkinsons disease, inhibitors/mutations on learning/memory
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Coughlin
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MON
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Bioinformatics &
genetics of murine/human serpins, plasmin-antiplasmin
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Deadman
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AMRD
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Inhibitors of
thromin and fibrinolysis proteases
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Dougan
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LaTr
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Chaperones and
bacterial/mitochondrial proteases, targeting misfolded proteins
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Fosang
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MEL
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Arthritis –
aggrecanase, MMPs, ADAMTS, ADAM 4&5 knockouts
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Guipponi
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WEHI
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Type II
Transmembrane Serine proteases in hearing loss; genetics, genomics
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Hawkins
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MCRI
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Human and
drosophila caspases and IAPs, apoptosis
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Irving
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MON
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Evolutionary,
biochemical, structural aspects of protease inhibitors called
serpins
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Mackie
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MON
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Thrombin and PARs
in bone and muscle cell biology
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Medcalf
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MON
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Fibrinolysis;
gene regulation; serine proteases; PAIs, tPA, uPA, plasmin,
draculin
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Nie
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MON
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Endometrial
proteases, proprotein convertases, HtrA, contraception,
infertility
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Perlmutter
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MON
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Beta amino acids
in inhibitors, cardiovascular metalloproteases, neuropeptides
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Pike
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MON
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Enzymology,
proteases in fibrinolysis./complement, bacteria & parasites
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Pritchard
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MON
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Functional
genomics, ADAMTS, ADAMTR-1 knockout, aggrecan, versican
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Salamonsen
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MON
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Endometrial
metalloproteases, activation by serine proteases, chemokines
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Scott
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WEHI
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Type II
Transmembrane Serine Proteases; genetics, genomics
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Smith
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BAK
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Cardiovascular
and brain Zn proteases, ACE-2 shedding, ECE, Neurolysin
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Smooker
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RMIT
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Cathepsin B- and
L- like secreted proteases from liver flukes and in vaccination
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Smyth
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PMc
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Granzymes and
viral infections, lymphocyte granule
exocytosis and cell death
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Thompson
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MEL
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Membrane type
MMPs in breast cancer progression
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Trapani
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PMc
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Cytotoxic
T lymphocytes, granzymes in immunopathology, apoptosis,
cancer
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Truscott
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LaTr
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Chaperones and
bacterial/mitochondrial proteases, targeting misfolded proteins
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Villangros
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WEHI
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Cathepsins and
cystatins in dendritic cells, knockouts, pathogen destruction
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Waltham
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MEL
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MMPs and
endogenous inhibitors in tumour growth, breast cancer, mestastasis
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Warner
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BAK
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Zinc
metallopeptidases, cell biology and physiology of ACE-2
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Whisstock
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MON
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Bioinformatics,
structures, functions of serpins and interactions with proteases
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ACT
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Baker
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ANU
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Ubiquitin-specific
cysteine proteases (USPs), proteosome
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Dean
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CAN
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Cellular disposal
of oxidised proteins, proteosomes and lysosomes
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East
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CSIRO
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Insect serine
proteases and digestion
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Hulett
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ANU
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Heparanase and
cancer
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Ollis
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ANU
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Protein crystal
structure of Hydrolyse
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SA
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Abbott
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FLIN
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Dipeptidylprolinases
(IV, 8, 9), metalloproteases, betacellulin shedding
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Kelly
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UA
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Genetics and
ubiqutin pathways
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Khew-Goodall
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IMVS
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Neutrophil
proteases and inhibitors, serpins, inflammatory diseases
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Kumar
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IMVS
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Drosophila
caspases, Nedd4 mediated ubiquitin regulating Na+
channels
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Roberts
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USA
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Ubiquitin pathway
and tumour suppressors
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Wood
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UA
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Roles of
deubiquitinating enzymes and intracellular trafficking
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