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Professor Jeffrey J Gorman
Institute for Molecular Bioscience
University of Queensland
Brisbane, Qld 4072
Email: j.gorman@imb.uq.edu.au
Tel: +61-7-3346-2995
Fax: +61-7-3214 2971
Homepage: http://www.imb.uq.edu.au/index.html?id=12018

We use proteomics to investigate the interaction between cellular proteases and viruses and viral proteases and cells. We also use proteomic mapping protein metabolism to define protease processing within cells. Activation of viral precursor proteins, particularly paramyxovirus fusion protein biosynthetic precursors, by host cellular proteins has been of interest for a long time because of an association with virulence. We are currently working collaborating with Dr Gerry Both of the CSIRO on processing of cellular cytoskeletal components by adenovirus proteases. Proteolytic processing of flavirus proteins also forms another interest. The mass spectrometry approaches used to study viral related proteolysis are also Immediately applicable to the study of any Intracellular or extracellular proteolysis system.
Dr Gerry Both, CSIRO Molecular Science
Associate Professor Paul Young, Microbiology, UQ
Dr Roy Hall, Microbiology, UQ
Gorman, J.J., Nestorowicz, A., Corino, G.L., Mitchell, S.J. and Selleck, P.W. (1988). Characterisation of the Sites of Proteolytic Activation of Newcastle Disease Virus Membrane Glycoprotein Precursors. Journal of Biological Chemistry. 263: 12522-12531.

Gorman, J.J., Corino, G.L. and Selleck, P.W. (1990). Comparison of the Positions and Efficiency of Cleavage-Activation of Fusion Protein Precursors of Virulent and Avirulent Strains of Newcastle Disease Virus: Insights into the Specificities of Activating Proteases. Virology. 177: 339-351.

Lopaticki, S., Morrow, C. J. and Gorman J. J. (1998) Characterization of Pathotype-Specific Epitopes of Newcastle Disease Virus Fusion Glycoproteins Isolates by Matrix-Assisted Laser Desorption/Ionisation Time-of-Flight Mass Spectrometry and Post-source Decay Sequencing. Journal of Mass Spectrometry. 33, 950-960.

Chen, L., Gorman, J. J., McKimm-Breshkin, J., Lawrence, L. J., Tulloch, P. A., Smith, B. J., Colman, P. M. and lawrence, M. C. (2001) Structure of the Fusion Glycoprotein of Newcastle Disease Virus. Structure. 9, 255-266.

Wallis, T. P., Huang, C.-Y., Nimkar S. B., Young P. R. and Gorman, J. J. Determination of the Disulfide Bond Arrangement of Dengue Virus NS1 Protein. J. Biol. Chem. (In Press)

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