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Dr Steven E Bottle
Synthesis and Molecular Recognition Research Program, Science Research Centre, Faculty of Science
Queensland University of Technology
Brisbane, Qld 4001
Email: s.bottle@qut.edu.au
Tel: +61-7-3864 1356
Fax: +61-7-3864 1804
Homepage: http://src.sci.qut.edu.au/programs/smr/leader.jsp

We are interested in free radical damage in biological systems, particularly proteins, by species collectively described as reactive oxygen species (ROS). Proteases and ROS form a crucial partnership in many biological functions, both detrimental and beneficial. When proteins are damaged by ROS they are susceptible to increased rates of digestion by intracellular proteases. We are exploring one way of limiting the negative role of ROS and proteases by using redox active drugs to control protein oxidation. We are also interested in the mechanisms of protein repair by small molecules such as nitric oxide and nitroxides. We have active research programs developing antioxidant drugs of particular impact in the brain where ROS activation of matrix metalloproteinases (MMP’s) disrupts the blood brain barrier as well as inactivating alpha 1 – protease inhibitor. These drugs show strong activity in neurological protection and are of interest in diseases such as Ataxia Telangiectasia and Parkinson’s disease.
Professor Michael Davies, Heart Research Institute
Professor Martin Lavin, Qld Institute of Medical Research
Professor Peter Scammells, Victorian College of Pharmacy
Professor Hal Swartz, Dartmouth Medical School
Professor Marc Greenberg, Johns Hopkins University
Chen, Philip; Peng, Cheng; Luff, John; Spring, Kevin; Watters, Dianne; Bottle, Steven; Furuya, Shigeki; Lavin, Martin F. Oxidative stress is responsible for deficient survival and dendritogenesis in Purkinje neurons from ataxia-telangiectasia mutated mutant mice. Journal of Neuroscience (2003), 23(36), 11453-11460.

Bottle, Steven E.; Hanson, Graeme R.; Micallef, Aaron S. Application of the new EPR spin trap 1,1,3-trimethylisoindole N-oxide (TMINO) in trapping HO.bul. and related biologically important radicals. Organic & Biomolecular Chemistry (2003), 1(14), 2585-2589.

Shen, J.; Bottle, S.; Khan, N.; Grinberg, O.; Reid, D.; Micallef, A.; Swartz, H. Development of isoindoline nitroxides for EPR oximetry in viable systems. Applied Magnetic Resonance (2002), 22(3), 357-368.

Bottle, Steven E.; Gillies, Duncan G.; Hughes, David L.; Micallef, Aaron S.; Smirnov, Alex I.; Sutcliffe, Leslie H. Synthesis, single crystal X-ray structure and W-band (95 GHz) EPR spectroscopy of a new anionic isoindoline aminoxyl: synthesis and characterization of some derivatives. Perkin 2 (2000), (7), 1285-1291.

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