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Professor Enrica Bosisio
Department of Pharmacological Sciences, Laboratory of Pharmacognosy Faculty of Pharmacy
Università degli Studi di Milano
Via Balzaretti,9 20133 Milano, Italia
Email: enrica.bosisio@unimi.it
Tel: +39-02-50318372
Fax: +39-02-50318284
Homepage: ttp://users.unimi.it/csr/ http://users.unimi.it/DPS/struttura.php?id=8

Our main research regards the field of medicinal plants and natural compounds from plant and sea origin with antimalarial and antiinflammatory properties. We are interested in the inhibition of proteases associated with human diseases, in particular aspartic proteases from Plasmodium falciparum (plasmepsins) and human proteases (metalloprotease and elastase). We have studied plant extracts on Plasmodium falciparum in vitro and identified polyphenolic compounds as inhibitors of plasmepsins. We also developed potent inhibitors of plasmepsins with high antiplasmodial activity.
Polyphenols from dietary source and secondary metabolites from medicinal herbs are being investigated for their antioxidant and anti-protease activity (secretion and gene expression of metalloprotease-9).
Mario Dell'Agli, Department of Pharmacological Mario Dell'Agli, Milan
Donatella Taramelli, Università degli Studi di Milano, Italy
Sergio Romeo, Università degli Studi di Milano, Italy
Michele D’Ambrosio, Università di Trento, Italy
Qihe Xu, King’s College, London, UK
E. Bosisio, D. Mascetti and P. Caballion. "Screening of plants from New Caledonia and Vanuatu for xanthine oxidase and elastase inhibitory activity". Pharm. Biol. 2000; 38, 18-24

M. Dell'Agli, S. Parapini, N. Basilico, L. Verotta, D. Taramelli, C. Berry, E. Bosisio "In Vitro studies on the mechanism of action of two compounds with antiplasmodial activity: ellagic acid and 3,4,5-trimethoxyphenyl (6'-O-galloyl)-β-D-glucopyranoside". Planta Med 2003, 69, 162-164

S. Bellosta, M. Dell'Agli, M. Canavesi, N. Mitro, M. Monetti, M. Crestani, L. Verotta, N. Fuzzati, F. Bernini, E. Bosisio "Inhibition of metalloproteinase-9 activity and gene expression by polyphenolic compounds isolated from the bark of Tristaniopsis calobuxus (Myrtaceae)". Cell. Mol. Life Sci. 2003, 60, 1440-1448

S. Romeo, M. Dell’Agli, S. Parapini, L. Rizzi, G. Galli, M. Mondani, A. Sparatore, D. Taramelli, E. BosisioPlasmepsin II inhibition and antiplasmodial activity of primaquine-statine “double drugs”. Bioorganic and Medicinal Chemistry Letters 2004, 14: 2931-2934

M. Dell’Agli, S. Bellosta, L. Rizzi, G.V. Galli, M. Canavesi, F. Rota, R. Parente, E. Bosisio, S. Romeo. A structure-activity study for the inhibition of metalloproteinase-9 activity and gene expression by analogues of gallocatechin-3-gallate. Cell. Mol. Life Sci. 2005, 62: 2896-2903

M. Dell’Agli, S.Parapini, G.Galli, N. Vaiana, D. Taramelli, A. Sparatore, P. Liu, B.M. Dunn, E. Bosisio, S. Romeo. High antiplasmodial activity of novel plasmepsin I and II inhibitors. J. Med. Chem. 2006, 49: 7440-9

S. Romeo, S. Parapini, M. Dell’Agli, N. Vaiana, P. Magrone, G. Galli, A. Sparatore, D. Taramelli, E. Bosisio. Atovaquone-Statine “Double-Drugs” with High Antiplasmodial Activity. Chemistry and Medicinal Chemistry 2008, 3: 410-20

M. Dell’Agli, G.V. Galli, E. Bosisio, M. D’ambrosio Inhibition of NF-kB and metalloproteinase-9 expression and secretion by parthenolide derivatives. Bioorganic and Medicinal Chemistry Letters 2009, 19: 1858-60

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