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Professor John Mayer
School of Biomedical Sciences
University of Nottingham
Medical School, QMC, Nottingham NG7 2UH
Email: John.Mayer@nottingham.ac.uk
Tel: +44 (0)115 9709480 ext. 41369
Fax: +44 115 970 9969

I have been privileged to research intracellular proteolysis and particularly the ubiquitin/proteasome system for 30 years. Regulated intracellular proteolysis has undergone a meteoric rise in importance to be seen as a new layer on the cake of cellular physiology. I am particularly interested in intracellular proteolysis in relation to neurodegenerative illnesses. I spend my time in the laboratory nationally and internationally furthering this field. I reviewed the state of play in the field in a review in 2000. The meteoric rise of regulated intracellular proteolysis. Nature Reviews in Molecular Cell Biology, 1, 145-148, 2000.

Current research interests
a) I have a group of two Postdoctoral Assistants, one Senior Experimental Officer, and 3 Research Students using transgenesis to delete key genes of the ubiquitin proteasome pathway conditionally in the brain of mice to recapitulate neuropathological features of Alzheimer’s disease, Parkinson’s disease, and Amyotophic lateral sclerosis.
b) In collaboration with Professor Jun Fujita, University of Kyoto, I am pursuing the functions of a novel proteasomal subunit called gankyrin which is overexpressed in hepatocellular carcinoma. Gankyrin is also found in other complexes in the cell which regulate the phosporylation and ubiquitylation of tumour suppressors.
Rezvani, K., Mee, M., Dawson, S., McIlhinney, J., Fujita, J. & Mayer, RJ. (2003) Proteasomal Interactors control activities as diverse as the cell cycle and glutaminergic neurotransmission. Biochem. Soc. Trans. 31, 1-4.

Mayer, R.J. (2003) From Neurodegeneration to Neurohomeostasis: the roles of ubiquitin. Drug News & perspectives. Prous Science, Barcelona. 16, 103-108.

Mayer, R.J., Rezvani, K., Layfield. R. & Dawson, S. (2003)
The ubiquitin pathway, neurodegeneration and brain function. Movement Disorders, 1, 14-16. (2003)

Nagoa, T., Higashitsuji, H., Nonoguchi, K., Sakurai, T., Dawson, S., Mayer, R.J., Itoh, K. & Fujita, J. (2003) MAGE-A4 interacts with the liver oncoprotein Gankyrin and suppresses its tumorigenic activity. J. Biol. Chem. 278, 10668-10674.

Krzywda, S., Brzozowski, A., Al-Safty, R., Welchman, R., Mee, M., Dawson, S., Fujita, J., Higashitsuji, H., Mayer, R.J. & Wilkinson, A. (2003) Crystallization of gankyrin, an oncoprotein that interacts with CDK4 and the S6b (rpt3) ATPase of the 19S regulator of the 26S proteasome. Acta Crystallographica D59, 1294-95. (2003)

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