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Professor Paul J Brindley
Department of Tropical Medicine
Tulane University
Department of Tropical Medicine, SL-17, Tulane University, Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana, 70112 USA
Email: paul.brindley@tulane.edu
Tel: +1 504 988 4645 (office), +1 504 988 6619 (lab)
Fax: +1 504 988 6686
Homepage: http://www.tulane.edu/~tropmed/

·Characterization of the phenomenon and biochemical pathways of proteolysis of ingested host hemoglobin in blood-feeding helminth parasites -- schistosomes and hookworms.
·Molecular basis for host specificity in hematophagous parasites including hookworms, schistosomes, etc: exploration of the contribution of parasite hemoglobin-digesting enzymes to host range and emerging infections.
·Exploration of the structure and function of retrotransposable elements in the schistosome genome
·Gene discovery, genome mapping and functional genomics for the human blood flukes, Schistosoma japonicum and S. mansoni
·Transgenesis studies with parasitic worms, including development of gene manipulation and knock down technologies targeting hemoglobin-digesting enzymes
·Exploration of methionine aminopeptidases of microsporidian parasites as novel targets for anti-microsporidian interventions.
John P. Dalton, Institute for Biotechnology of Infectious Diseases, UTS Sydney, Australia
Elizabeth S. Didier, Tulane National Primate Center, Tulane University, Covington, Louisiana
Alex Loukas, George Washington Univ., Dept. of Microbiol. & Tropical Medicine, Washington, D.C.
Bernd H. Kalinna, Institute of Biology, Humboldt University, Berlin, Germany
Edward Pearce, Department of Pathobiology, University of Pennsylvania, Philadelphia PA, USA
Franklin A. Neva, National Institutes of Health, Laboratory of Parasitic Diseases, Maryland
David Fairlie and Giovanni Abbenante, Institute of Molecular Biosciences, Univ of Queensland, Australia
McCarthy, E., Donnelly, S.M., Stack, C., Doyle, S., Mann, V.M., Brindley, P.J., Stewart, M., Day, T.A., Maule, A.G., Dalton, J.P. (2004) Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum. International Journal for Parasitology, in press.

Didier, E.S., Martin, A.D., Stovall, M.E., Alvarez , X., Mittleider, D., Green, L.S., Bowers, L.C., Plauche, A.,.Didier, P.J., Brindley, P.J., (2003) Methionine aminopeptidase 2 expression in microsporidia. Journal of Eukaryotic Microbiology 50, 569-571.

Williamson, A.L., Brindley, P.J., Abbenante, G., Prociv, P., Berry, C., Girdwood, K., Pritchard, D.I., Fairlie, D.P., Hotez, P.J., Dalton, J.P., Loukas, A. (2002) Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity. FASEB Journal 16, 1458-1460.

Brindley, P.J., Kalinna, B.H., Wong, J.Y.M., Bogitsh, B.J., King, L.T., Smyth, D.J., Verity, C.K., Abbenante, G., Brinkworth, R.I., Fairlie, D.P., Smythe, M.L., Milburn, P.J., Bielefeldt-Ohmann, H., Zheng, Y., McManus, D.P. (2001) Proteolysis of human hemoglobin by schistosome cathepsin D. Molecular and Biochemical Parasitology 112, 103-112.

Brinkworth, R.I., Prociv, P., Loukas, A., Brindley, P.J. (2001) Hemoglobin-degrading, aspartic proteases of blood-feeding parasites: Substrate specificity revealed by homology models. Journal of Biological Chemistry 276, 38844-38851.

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