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Dr John Abbenante
Institute for Molecular Bioscience
University of Queensland
Brisbane,Qld 4072, Australia
Email: j.abbenante@imb.uq.edu.au
Tel: +61-7-3346-2991
Fax: +61-7-3346-2101 or 2103

I am interested in the discovery of new approaches for the design of inhibitors of the four major classes of proteases and new methods for the synthesis of inhibitors and substrates. I am particularly interested in applying these to the development of marketable drugs. Current research projects include, the development of inhibitors of the complement convertases, and new approaches for the development of cysteine protease inhibitors, particularly the caspases involved in apoptosis and inflammation. I am also actively involved in aspartic protease inhibitor design and development for HIV1-PR, Human cathepsin D, proteases involved in Alzheimers disease as well as the development of specific inhibitors of novel schistosomal and hookworm aspartic proteases involved in haemoglobin degradation by the respective parasites. I have also worked on the development of biologically stable inhibitors of the metalloprotease EC 24.15, an enzyme involved in hypertension. Other relevant research includes the development of inhibitors/substrates for the Dengue Virus NS3 protease, the West Nile NS3 protease and a novel cone snail protease, as well as the development of a simple method for the synthesis of p-nitroanilide substrates.
Leung, D., Abbenante, G., Fairlie, D. P. ‘Protease Inhibitors: Current Status and future prospects’ J. Med. Chem. 2000, 43: (3) 305-341.

Smith, A.I., Lew, R.A., Shrimpton, C.N., Evans, R.G., Abbenante, G., ‘A novel stable inhibitor of endopeptidases EC and EC potentiates bradykinin-induced hypotension', Hypertension, 2000, 35: (2) 626-630.

Milne TJ, Abbenante, G., Tyndall J., Lewis R.J., Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily J. Biol. Chem. 2003, 278 (33): 31105-31110.

Abbenante, G., Kovacs, D.M., Leung, D.L., Craik, D.J., Tanzi, R.E., Fairlie, D.P., ‘Inhibitors of Beta-amyloid Formation based on the Beta-Secretase Cleavage Site’. Biochem. Bioph. Res. Co. 2000, 268: (1) 133-135.

Abbenante, G., March, D., Bergman, D., Dancer, R., Garnham, B.,Hunt, P., James, I., Martin, J., Fairlie, D.P., ‘Regioselective structural and functional mimicry of peptides. Design of hydrolytically stable cyclic peptidomimetics inhibitors of HIV-1 protease’, J. Am. Chem. Soc., 1995, 117, 10220-10226.

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