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Dr Dimitri M Odorico
Hormone-Dependent Cancer Program, Science Research Centre, School of Life Sciences
Queensland University of Technology
Brisbane, Qld 4001
Email: d.odorico@qut.edu.au
Tel: +61-7-3864-5215
Fax: +61-7-3864-1534

The focus of our research is in the ADAMs family of metalloproteases, (so called because they possess A Disintegrin And Metalloprotease domain) and their association with the progression of hormone-dependent cancers, in particular prostate cancer. Classically, the ADAMs are characterised as cell surface sheddases, with demonstrated abilities to activate and/or solubilize cell surface growth factors and cytokines. Our current work is directed towards a better understanding of the mechanisms involved in the regulation of these proteases and investigating the roles that ADAMs may play at both the extracellular and intracellular level. Additional research includes work with the kallikreins in cancer progression.
Prof Rik Thompson (University of Melbourne, Australia)
Dr Elizabeth Williams (University of Melbourne, Australia)
Prof Judith Clements (Queensland University of Technology, Australia)
Prof Adrian Herington (Queensland University of Technology, Australia)
McCulloch DR, Akl P, Samaratunga H, Herington AC , Odorico DM. Expression of the Disintegrin Metalloprotease, ADAM-10, in Prostate Cancer and Its Regulation by Dihydrotestosterone, Insulin-Like Growth Factor I, and Epidermal Growth Factor in the Prostate Cancer Cell Model LNCaP. Clin Cancer Res. 2004 Jan 1;10 (1) :in press.

Clements, JA., Hooper, JD., Odorico, DM. and Dong, Y. ?The tissue kallikrein gene cluster? in the Handbook of Proteolytic Enzymes, 2nd edition, (Eds; AJ Barrett, ND Rawlings, JF Woessner.) Academic Press, London. 16 February 2004.

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