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Professor Sharad Kumar*
Hanson Institute
Cancer for Cancer Biology SA Pathology
Frome Road, Adelaide 5000
Email: sharad.kumar@health.sa.gov.au
Tel: +61-8-8222-3738
Fax: +61-8-8222-3139
Homepage: http://www.imvs.sa.gov.au/haematology/research/MolReg/MolReg.html

The two major interests of our laboratory are: (1) the study of programmed cell death (apoptosis) of normal and cancer cells, with a special focus on caspases, and (2) regulation of protein stability and trafficking by ubiquitination.
Apoptosis plays a fundamental role in cell and tissue homeostasis and its misregulation results in a variety of human diseases including many types of cancer. We are studying the function and regulation of caspases, a group of proteases that act as effectors of apoptosis.
Ubiquitin-mediated protein modification plays an essential role in cellular regulation. Recent studies suggest that ubiquitination is a major regulator of many ion channels, receptors and transporters. We are studying the function of a group of ubiquitin-protein ligating enzymes (Nedd4-like proteins). The Nedd4 family of ubiquitin ligases belongs to the HECT class of E3s. We are using a variety of molecular, cellular and gene knockout approaches to study the physiological functions of these enzymes. We are also studying a group of proteins that regulate the function of the Nedd4 family of E3s.
Professor Baoli Yang, University of Iowa
Professor David Cook and Dr Anuwat Dinudom, University of Sydney
Professor Philip Poronnik, RMIT
Professor Seong-Seng Tan, Howard Florey Institute
Professor Eric Baehrecke, University of Massachusetts Medical School
FFotia AB, Ekberg J, Cook DI, Adams DJ, Poronnik P, Kumar S (2004) Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. J. Biol. Chem. 279: 28930-28935.

Baliga BC, Read SH, Kumar S (2004) The biochemical mechanism of caspase-2 activation. Cell Death Differ. 11: 1234-1241.

Dorstyn L, Mills K, Lazebnik Y, Kumar S (2004) The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells. J. Cell Biol. 167: 405-410.

Daish TJ, Mills K, Kumar S (2004) Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis. Developmental Cell 7: 909-915.

Kumar S (2007) Caspase function in programmed cell death. Cell Death Differ. 14: 32-43.

Ho LH, Dorstyn L, Lambrusco, L, Read SH, Kumar S (2008) Caspase-2 is required for cell death induced by cytoskeletal disruption. Oncogene 27: 3393-3404.

Foot NJ, Dalton HE, Shearwin-Whyatt LM, Dorstyn L, Tan SS, Yang, B, Kumar S (2008) Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood 112: 4268-4275.
Cao XR, Lill NL, Boase N, Shi PP, Croucher D, Shan H, Qu J, Sweezer EM, Place T, Kirby PA, Daly RJ, Kumar S*, Yang B* (2008) Nedd4 controls animal growth by regulating IGF-1 signaling. Science Signaling. 1: ra5. (*joint-senior authors)

Ho LH, Taylor R, Cakouros D, Dorstyn L, Bouillet P, Kumar S (2009) A tumor suppressor function for caspase-2. Proc. Natl. Acad. Sci. USA 106: 5336-5341.

Rotin D, Kumar S (2009) Physiological functions of the HECT family of ubiquitin ligases. Nature Rev. Mol. Cell Biol. 10: 398-409.

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