Welcome to !

Dr Ying Dong
Hormone Dependent Cancer Program, Cluster of Molecular Biotechnology, School of Life Sciences
Queensland University of Technology
Gardens Point Campus, Brisbane, QLD, 4001, Australia
Email: y.dong@qut.edu.au
Tel: +61-7-38645215
Fax: +61-7-38641534

Our interests are female hormone dependent cancer associated human proteases that are involved in tumorigenesis and tumour progression. Kallikreins are a subgroup of serine proteases that are associated with numerous human disorders, including ovarian cancer, breast cancer and endometrial carcinomas. Recently we have shown that several kallikreins are up-regulated in epithelial ovarian cancer in comparison to the normal ovarian epithelial cells at mRNA and protein level. These kallikreins may not only have the potential as diagnostic and prognostic markers, but may be useful in therapeutic approaches as well. The functions of this group of serine proteases are mainly to do with post-translational modifications, such as cleavage of pre-pro-enzymes. It has been found that some of the kallikreins are involved in the degradation of the extracellular matrix and in cell proliferation, both being important in tumour progression. We are looking at the functional role of these kallikreins in such processes.
Dong Y, Berners-Price SJ, Thorburn DR, Antalis T, Dickinson J, Hurst T, Qiu L, Khoo SK, and Parsons PG: Serine protease inhibition and mitochondrial dysfunction associated with cisplatin resistance in human tumour cell lines: targets for therapy. Biochem Pharmacol 53: 1673-1682 (1997).

Clements J, Hooper J, Dong Y and Harvey T: The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential function (Minireview) Biol Chem 382: 5-14, 2001

Dong Y, Kaushal A, Bui L, Fuller P, Chu S, Nicklin J, and Clements JA: Kallikrein 4/KLK4 is highly expressed in serous ovarian carcinomas. Clin Cancer Res 7: 2363, 2001.

Harvey J, Dong Y, Bui L, Jarrott R, Walsh T, and Clements JA. “Production and Characterization of anti-peptide kallikrein 4 antibodies: use of computer modelling to design peptides specific to kallikrein 4”in vol: Prostate Cancer: Methods and Protocols, Ed. Russell PJ, Jackson P, and Kingsley EA, P Humana Press, New Jersey. pp241-254, 2003

Dong Y, Brettsand M, Kaushal A, Nicklin J, and Clements JA: Differential Splicing of KLK5 and KLK7 in Epithelial Ovarian Cancer Produces Novel Variants with Potential as Cancer Biomarkers. Clin Cancer Res 2003 9(5): 1710-20

Questions/suggestions? Please contact the Network Administrator.
Copyright © by International Protease Network All Right Reserved.