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Dr Yeesim Khew-Goodall
Hanson Institute
Institute of Medical and Veterinary Science
Frome Road, Adelaide, SA 5000
Email: yeesim.khew-goodall@imvs.sa.gov.au
Tel: +61-8-8222 3410
Fax: +61-8-82324092

Neutrophils (and monocytes) produce proteases that are essential for the eradication of infections but these proteases also play an important role in inflammation and tissue injury. In particular, neutrophil proteases are responsible for the tissue damage and inflammation that characterise hereditary emphysema, chronic obstructive pulmonary diseases, cystic fibrosis, adult respiratory distress syndrome, ischaemic reperfusion injury and rheumatoid arthritis. My laboratory is interested in the mechanisms of neutrophil transmigration across the blood vessel wall during inflammation, as well as the roles played by neutrophils in mediating various inflammatory conditions. In studies to elucidate novel signalling pathways that regulate neutrophil extravasation, we have recently begun investigating the roles of neutrophil proteases and their inhibitors in this process.
A balance between amounts of proteases and their inhibitors serves to limit the extent of the inflammatory response and resultant tissue damage. There is recently also evidence suggesting that the Serpin family of protease inhibitors can play a role in tissue repair processes in a manner independent of their inhibitory action on the proteases. Our recent studies also indicate that inhibitors of neutrophil proteases may be involved in regulating neutrophil extravasation. Using a proteomics approach, we aim to identify the proteases and inhibitors involved in this process and determine their precise role and mechanism of action in neutrophil transmigration.

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